Join us on May 2, 2026, in Cape Girardeau, Missouri, for the 6th Annual Muddy River Half Marathon—a mostly flat route along roads and paved trails that showcases local landmarks including the Bill Emerson Bridge, Common Pleas Courthouse, and Old St. Vincent's Church, culminating at the riverfront near Century Casino. Your registration fee directly supports regional non-profits focused on health and wellness initiatives, with more than $100,000 contributed to date and ongoing expansion of funding to additional organizations throughout Southeast Missouri. Run knowing that you're helping strengthen your community while enjoying a scenic finish!